Version 5.4
Mus musculus Protein: Reg3b
Summary
InnateDB Protein IDBP-158447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Reg3b
Protein Name regenerating islet-derived 3 beta
Synonyms HIP; Pap; PAP1; REG-III;
Species Mus musculus
Ensembl Protein ENSMUSP00000094667
InnateDB Gene IDBG-158443 (Reg3b)
Protein Structure
UniProt Annotation
Function Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues. {ECO:0000269PubMed:21694778, ECO:0000269PubMed:22252863}.
Subcellular Localization Secreted. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000250}.
Disease Associations Note=Overexpressed during the acute phase of pancreatitis.
Tissue Specificity Constitutively expressed in the small intestine, moderately in colon and at an extremely low level in healthy pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0006953 acute-phase response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:97478
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35230
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 18489
UniGene Mm.393752
RefSeq NP_035166
MGI ID
MGI Symbol Reg3b
OMIM
CCDS CCDS20253
HPRD
IMGT
EMBL BC027525 D13509 D63359 D63360
GenPept AAH27525 BAA02727 BAA18928 BAA18929

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca