Version 5.4
Mus musculus Protein: Reg3a
Summary
InnateDB Protein IDBP-158449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Reg3a
Protein Name regenerating islet-derived 3 alpha
Synonyms AV063448;
Species Mus musculus
Ensembl Protein ENSMUSP00000098829
InnateDB Gene IDBG-252681 (Reg3a)
Protein Structure
UniProt Annotation
Function Bactericidal C-type lectin (By similarity). Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. {ECO:0000250, ECO:0000269PubMed:22727489}.
Subcellular Localization Secreted.
Disease Associations Note=Overexpressed during the acute phase of pancreatitis.
Tissue Specificity Small intestine and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0006953 acute-phase response
GO:0010838 positive regulation of keratinocyte proliferation
GO:0045617 negative regulation of keratinocyte differentiation
GO:0090303 positive regulation of wound healing
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:109408
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O09037
PhosphoSite PhosphoSite-
TrEMBL Q9CQE4
UniProt Splice Variant
Entrez Gene 19694
UniGene Mm.2552
RefSeq NP_035389
MGI ID
MGI Symbol Reg3a
OMIM
CCDS CCDS20255
HPRD
IMGT
EMBL AB035203 AK008050 AK008140 BC119153 CH466523 D63356 D63357 D63358
GenPept AAI19154 BAA18925 BAA18926 BAA18927 BAA88563 BAB25430 BAB25488 EDK99017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca