InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF2E2

Summary

InnateDB Protein

IDBP-15847.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2E2

Protein Name

general transcription factor IIE, polypeptide 2, beta 34kDa

Synonyms

FE; TF2E2; TFIIE-B;

Species

Homo sapiens

Ensembl Protein

ENSP00000348168

InnateDB Gene

IDBG-15845 (GTF2E2)

Protein Structure

UniProt Annotation

Function

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process