Version 5.4
Mus musculus Protein: Nop58
Summary
InnateDB Protein IDBP-158513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nop58
Protein Name NOP58 ribonucleoprotein homolog (yeast)
Synonyms MSSP; Nol5; nop5; SIK;
Species Mus musculus
Ensembl Protein ENSMUSP00000027174
InnateDB Gene IDBG-158511 (Nop58)
Protein Structure
UniProt Annotation
Function Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030515 snoRNA binding
GO:0030519 snoRNP binding
Biological Process
GO:0006608 snRNP protein import into nucleus
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0070761 pre-snoRNP complex
Protein Structure and Domains
PDB ID MGI:1933184
InterPro IPR002687 Nop domain
IPR012974 NOP5, N-terminal
IPR012976 NOSIC
PFAM PF01798
PF08156
PF08060
PRINTS
PIRSF
SMART SM00931
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6DFW4
PhosphoSite PhosphoSite-Q6DFW4
TrEMBL
UniProt Splice Variant
Entrez Gene 55989
UniGene Mm.220367
RefSeq
MGI ID
MGI Symbol Nop58
OMIM
CCDS
HPRD
IMGT
EMBL AF053232 AK044216 AK133959 AK134286 BC076604 BC085135
GenPept AAC08435 AAH76604 AAH85135 BAC31822 BAE21954 BAE22082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca