InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acaa2

Summary

InnateDB Protein

IDBP-158531.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acaa2

Protein Name

acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)

Synonyms

0610011L04Rik; AI255831; AI265397; D18Ertd240e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037348

InnateDB Gene

IDBG-158529 (Acaa2)

Protein Structure

UniProt Annotation

Function

Abolishes BNIP3-mediated apoptosis and mitochondrial damage. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}. Note=Colocalizes with BNIP3 in the mitochondria. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003988	acetyl-CoA C-acyltransferase activity
GO:0005515	protein binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006631	fatty acid metabolic process
GO:0008152	metabolic process
GO:0071456	cellular response to hypoxia
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process