InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fos

Summary

InnateDB Protein

IDBP-158540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fos

Protein Name

FBJ osteosarcoma oncogene

Synonyms

c-fos; cFos; D12Rfj1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021674

InnateDB Gene

IDBG-158538 (Fos)

Protein Structure

UniProt Annotation

Function

Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000250, ECO:0000269PubMed:12134156, ECO:0000269PubMed:12972619, ECO:0000269PubMed:15719069, ECO:0000269PubMed:21998197, ECO:0000269PubMed:22105363}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	35 [view]
Protein-DNA	26 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	154 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070412	R-SMAD binding

Biological Process

GO:0001661	conditioned taste aversion
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007399	nervous system development
GO:0007565	female pregnancy
GO:0007568	aging
GO:0009409	response to cold
GO:0009416	response to light stimulus
GO:0009612	response to mechanical stimulus
GO:0009629	response to gravity
GO:0009636	response to toxic substance
GO:0014070	response to organic cyclic compound
GO:0030431	sleep
GO:0031668	cellular response to extracellular stimulus
GO:0032496	response to lipopolysaccharide
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0034097	response to cytokine
GO:0034614	cellular response to reactive oxygen species
GO:0035902	response to immobilization stress
GO:0035914	skeletal muscle cell differentiation
GO:0042493	response to drug
GO:0045672	positive regulation of osteoclast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0060395	SMAD protein signal transduction
GO:0071277	cellular response to calcium ion