InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psme4

Summary

InnateDB Protein

IDBP-158629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psme4

Protein Name

proteasome (prosome, macropain) activator subunit 4

Synonyms

AA409398; AU041366; mKIAA0077; TEMO;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045460

InnateDB Gene

IDBG-158627 (Psme4)

Protein Structure

UniProt Annotation

Function

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269PubMed:16581775, ECO:0000269PubMed:23706739}.

Subcellular Localization

Cytoplasm, cytosol. Nucleus. Nucleus speckle {ECO:0000250}. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2). {ECO:0000250}.

Disease Associations

Tissue Specificity

Broadly expressed. Present in heart (at protein level). {ECO:0000269PubMed:12093752, ECO:0000269PubMed:16857966}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0016504	peptidase activator activity
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007275	multicellular organismal development
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0010952	positive regulation of peptidase activity
GO:0035093	spermatogenesis, exchange of chromosomal proteins