InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aif1l

Summary

InnateDB Protein

IDBP-158663.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aif1l

Protein Name

allograft inflammatory factor 1-like

Synonyms

2810003C17Rik; AI043124; C87647; Iba2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001920

InnateDB Gene

IDBG-158661 (Aif1l)

Protein Structure

UniProt Annotation

Function

Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0051015	actin filament binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0032587	ruffle membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome