InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: JSRP1

Summary

InnateDB Protein

IDBP-15868.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JSRP1

Protein Name

junctional sarcoplasmic reticulum protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300961

InnateDB Gene

IDBG-15866 (JSRP1)

Protein Structure

UniProt Annotation

Function

Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269PubMed:22927026}.

Subcellular Localization

Sarcoplasmic reticulum membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0072657	protein localization to membrane