InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Papss2

Summary

InnateDB Protein

IDBP-158693.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Papss2

Protein Name

3'-phosphoadenosine 5'-phosphosulfate synthase 2

Synonyms

1810018P12Rik; AI159688; Atpsk2; AtpsU2; bm; Sk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025833

InnateDB Gene

IDBG-158691 (Papss2)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important role in skeletogenesis during postnatal growth.

Subcellular Localization

Disease Associations

Note=Defects in Papss2 are the cause of brachymorphism (bm), a autosomal recessive disease, which is characterized by abnormal hepatic detoxification, bleeding times and postnatal growth, such as dome-shaped skull, short thick tail, and shortened but not widened limbs. The abnormal postnatal growth has been attributed to undersulfation of cartilage proteoglycans.

Tissue Specificity

Expressed in liver, cartilage, skin and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004020	adenylylsulfate kinase activity
GO:0004781	sulfate adenylyltransferase (ATP) activity
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity

Biological Process

GO:0000103	sulfate assimilation
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0060348	bone development

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1330223

InterPro

IPR002650 Sulphate adenylyltransferase
IPR002891 Adenylylsulphate kinase
IPR015947 PUA-like domain
IPR024951 Sulphate adenylyltransferase catalytic domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01583
PF01747

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88428

PhosphoSite