Version 5.4
Mus musculus Protein: Tab3
Summary
InnateDB Protein IDBP-158741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tab3
Protein Name TGF-beta activated kinase 1/MAP3K7 binding protein 3
Synonyms 4921526G09Rik; Map3k7ip3; mKIAA4135;
Species Mus musculus
Ensembl Protein ENSMUSP00000039668
InnateDB Gene IDBG-158739 (Tab3)
Protein Structure
UniProt Annotation
Function Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL-1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1913974
InterPro IPR001876 Zinc finger, RanBP2-type
IPR003892 Ubiquitin system component Cue
PFAM PF00641
PF02845
PRINTS
PIRSF
SMART SM00547
SM00546
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q571K4
PhosphoSite PhosphoSite-Q571K4
TrEMBL F7AT87
UniProt Splice Variant
Entrez Gene 66724
UniGene Mm.119646
RefSeq NP_080005
MGI ID 3A9K
MGI Symbol Tab3
OMIM
CCDS CCDS41049
HPRD
IMGT
EMBL AK220185 AL645567 AL645586 BC139024 BC139025
GenPept AAI39025 AAI39026 BAD90370

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca