InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tktl2

Summary

InnateDB Protein

IDBP-158744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tktl2

Protein Name

transketolase-like 2

Synonyms

4933401I19Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002025

InnateDB Gene

IDBG-158742 (Tktl2)

Protein Structure

UniProt Annotation

Function

Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004802	transketolase activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976	thiamine pyrophosphate binding
GO:0046872	metal ion binding

Biological Process

GO:0008152

metabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1921669

InterPro

IPR001017 Dehydrogenase, E1 component
IPR005474 Transketolase, N-terminal
IPR005475 Transketolase-like, pyrimidine-binding domain
IPR005476 Transketolase, C-terminal
IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF00676
PF00456
PF02779
PF02780
PF02775

PRINTS

PIRSF

SMART

SM00861

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D4D4