Version 5.4
Mus musculus Protein: Wdr12
Summary
InnateDB Protein IDBP-158834.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr12
Protein Name WD repeat domain 12
Synonyms 4933402C23Rik; Ytm1; Ytm1p;
Species Mus musculus
Ensembl Protein ENSMUSP00000027173
InnateDB Gene IDBG-158832 (Wdr12)
Protein Structure
UniProt Annotation
Function Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255HAMAP-Rule:MF_03029}.
Subcellular Localization Nucleus, nucleolus {ECO:0000255HAMAP- Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255HAMAP- Rule:MF_03029}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219 Notch signaling pathway
GO:0008283 cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex
Protein Structure and Domains
PDB ID MGI:1927241
InterPro IPR001680 WD40 repeat
IPR012972 NLE
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PF08154
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJA4
PhosphoSite PhosphoSite-Q9JJA4
TrEMBL Q4V9X1
UniProt Splice Variant
Entrez Gene 57750
UniGene Mm.488803
RefSeq NP_067287
MGI ID
MGI Symbol Wdr12
OMIM
CCDS CCDS14988
HPRD
IMGT
EMBL AB041608 AC116581 AF239765 AK007500 AK012022 AK016611 AK031436 AK149085 AK161299 AY059431 AY059432 BC004748 BC052386 BC096651 CH466548
GenPept AAF44683 AAH04748 AAH52386 AAH96651 AAL29680 AAL29681 BAA95091 BAB25072 BAB27979 BAB30336 BAC27402 BAE28733 BAE36306 EDL00140 EDL00141 EDL00142

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca