InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Csf2rb2

Summary

InnateDB Protein

IDBP-158860.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Csf2rb2

Protein Name

colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)

Synonyms

AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb; Il3rb2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000094083

InnateDB Gene

IDBG-158858 (Csf2rb2)

Protein Structure

UniProt Annotation

Function

In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0019221

cytokine-mediated signaling pathway

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1339760

InterPro

IPR003961 Fibronectin, type III
IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
IPR015152 Growth hormone/erythropoietin receptor, ligand binding
IPR015321 Interleukin-6 receptor alpha, binding
IPR015373 Interferon alpha/beta receptor, beta chain

PFAM

PF00041
PF01108
PF09067
PF09240
PF09294

PRINTS

PIRSF

PIRSF001956

SMART

SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt