InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pten

Summary

InnateDB Protein

IDBP-158880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pten

Protein Name

phosphatase and tensin homolog

Synonyms

2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; MMAC1; TEP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013807

InnateDB Gene

IDBG-158878 (Pten)

Protein Structure

UniProt Annotation

Function

In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (By similarity). Tumor suppressor. Acts as a dual- specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K- AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. {ECO:0000250, ECO:0000269PubMed:10339565, ECO:0000269PubMed:19778506}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Monoubiquitinated form is nuclear (By similarity). Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies. XIAP/BIRC4 promotes its nuclear localization. {ECO:0000250, ECO:0000269PubMed:19473982}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	21 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004438	phosphatidylinositol-3-phosphatase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0010997	anaphase-promoting complex binding
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016791	phosphatase activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0030165	PDZ domain binding
GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

Biological Process

GO:0001525	angiogenesis
GO:0001933	negative regulation of protein phosphorylation
GO:0002902	regulation of B cell apoptotic process
GO:0006470	protein dephosphorylation
GO:0006915	apoptotic process
GO:0007092	activation of mitotic anaphase-promoting complex activity
GO:0007270	neuron-neuron synaptic transmission
GO:0007416	synapse assembly
GO:0007417	central nervous system development
GO:0007507	heart development
GO:0007568	aging
GO:0007584	response to nutrient
GO:0007611	learning or memory
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009749	response to glucose
GO:0010033	response to organic substance
GO:0010035	response to inorganic substance
GO:0010043	response to zinc ion
GO:0010975	regulation of neuron projection development
GO:0014070	response to organic cyclic compound
GO:0016311	dephosphorylation
GO:0016477	cell migration
GO:0021542	dentate gyrus development
GO:0021955	central nervous system neuron axonogenesis
GO:0030336	negative regulation of cell migration
GO:0031175	neuron projection development
GO:0031642	negative regulation of myelination
GO:0031647	regulation of protein stability
GO:0031658	negative regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032286	central nervous system myelin maintenance
GO:0032355	response to estradiol
GO:0032535	regulation of cellular component size
GO:0033032	regulation of myeloid cell apoptotic process
GO:0033198	response to ATP
GO:0033555	multicellular organismal response to stress
GO:0035176	social behavior
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042493	response to drug
GO:0042711	maternal behavior
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043491	protein kinase B signaling
GO:0043542	endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045475	locomotor rhythm
GO:0045792	negative regulation of cell size
GO:0046621	negative regulation of organ growth
GO:0046685	response to arsenic-containing substance
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048738	cardiac muscle tissue development
GO:0048853	forebrain morphogenesis
GO:0048854	brain morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050765	negative regulation of phagocytosis
GO:0050771	negative regulation of axonogenesis
GO:0050821	protein stabilization
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051726	regulation of cell cycle
GO:0051895	negative regulation of focal adhesion assembly
GO:0051898	negative regulation of protein kinase B signaling
GO:0060024	rhythmic synaptic transmission
GO:0060070	canonical Wnt signaling pathway
GO:0060074	synapse maturation
GO:0060134	prepulse inhibition
GO:0060179	male mating behavior
GO:0060291	long-term synaptic potentiation
GO:0060292	long term synaptic depression
GO:0060736	prostate gland growth
GO:0060997	dendritic spine morphogenesis
GO:0061002	negative regulation of dendritic spine morphogenesis
GO:0090071	negative regulation of ribosome biogenesis
GO:0090344	negative regulation of cell aging
GO:0090394	negative regulation of excitatory postsynaptic membrane potential
GO:0097105	presynaptic membrane assembly
GO:0097107	postsynaptic density assembly
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
GO:2000463	positive regulation of excitatory postsynaptic membrane potential
GO:2000808	negative regulation of synaptic vesicle clustering
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0016605	PML body
GO:0035749	myelin sheath adaxonal region
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0043220	Schmidt-Lanterman incisure
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:109583

InterPro

IPR000008 C2 domain
IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR014020 Tensin phosphatase, C2 domain
IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
IPR029021 Protein-tyrosine phosphatase-like
IPR029023 Tensin phosphatase, lipid phosphatase domain

PFAM

PF00168
PF00102
PF00782
PF10409

PRINTS

PR00360
PR00700

PIRSF

PIRSF038025

SMART

SM00239
SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References