Version 5.4
Mus musculus Protein: Ppapdc3
Summary
InnateDB Protein IDBP-158889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppapdc3
Protein Name phosphatidic acid phosphatase type 2 domain containing 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000054337
InnateDB Gene IDBG-158887 (Ppapdc3)
Protein Structure
UniProt Annotation
Function Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity. Knockdown in myoblasts strongly promotes differentiation, whereas overexpression represses myogenesis. {ECO:0000269PubMed:19704009}.
Subcellular Localization Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm.
Disease Associations
Tissue Specificity Highly expressed in heart and muscle. {ECO:0000269PubMed:17062158, ECO:0000269PubMed:19704009}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
Biological Process
GO:0008152 metabolic process
GO:0010832 negative regulation of myotube differentiation
Cellular Component
GO:0005635 nuclear envelope
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2445183
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91WB2
PhosphoSite PhosphoSite-Q91WB2
TrEMBL
UniProt Splice Variant
Entrez Gene 227721
UniGene Mm.400298
RefSeq NP_663496
MGI ID
MGI Symbol Ppapdc3
OMIM
CCDS CCDS15906
HPRD
IMGT
EMBL AK052883 AK134638 BC016136
GenPept AAH16136 BAC35188 BAE22220

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca