InnateDB Protein
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IDBP-158969.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rnls
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Protein Name
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renalase, FAD-dependent amine oxidase
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Synonyms
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6530404N21Rik; AI452315; AW060440; C10orf59;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000093825
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InnateDB Gene
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IDBG-158965 (Rnls)
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Protein Structure
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Function |
Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:17846919}.
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Disease Associations |
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Tissue Specificity |
Expressed predominantly in kidney and testis with lower levels in liver, heart and embryo and weak expression in brain and skeletal muscle. {ECO:0000269PubMed:17846919}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0016491
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oxidoreductase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915045
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InterPro |
IPR002937
Amine oxidase
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PFAM |
PF01593
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A7RDN6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
E9Q243
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UniProt Splice Variant |
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Entrez Gene |
67795
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UniGene |
Mm.204591
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RefSeq |
NP_001161290
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MGI ID |
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MGI Symbol |
Rnls
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OMIM |
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CCDS |
CCDS50416
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HPRD |
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IMGT |
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EMBL |
AC117183
AC125381
AC160088
AK170321
BC052355
DQ788834
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GenPept |
AAH52355
ABG82016
BAE41716
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