Version 5.4
Mus musculus Protein: Erlec1
Summary
InnateDB Protein IDBP-158990.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Erlec1
Protein Name endoplasmic reticulum lectin 1
Synonyms 4933407N01Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000072929
InnateDB Gene IDBG-158988 (Erlec1)
Protein Structure
UniProt Annotation
Function Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
Biological Process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID MGI:1914003
InterPro IPR009011 Mannose-6-phosphate receptor binding domain
IPR012913 Glucosidase II beta subunit-like
PFAM PF07915
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VEH8
PhosphoSite PhosphoSite-
TrEMBL Q3TRQ6
UniProt Splice Variant
Entrez Gene 66753
UniGene Mm.294641
RefSeq NP_080021
MGI ID
MGI Symbol Erlec1
OMIM
CCDS CCDS24509
HPRD
IMGT
EMBL AK077120 AK133874 AK162571 AL662891 BC018468
GenPept AAH18468 BAC36623 BAE21904 BAE36971 CAI24536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca