Version 5.4
Mus musculus Protein: Psd3
Summary
InnateDB Protein IDBP-159001.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psd3
Protein Name pleckstrin and Sec7 domain containing 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096293
InnateDB Gene IDBG-158999 (Psd3)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor for ARF6. {ECO:0000269PubMed:16707115}.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269PubMed:16707115}.
Disease Associations
Tissue Specificity Ubiquitously expressed, with highest levels in liver. Present in brain, with highest levels in olfactory bulb, cortex, hippocampal pyramidal cell layer and cerebellar granule cell layer (at protein level). {ECO:0000269PubMed:16707115}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
Biological Process
GO:0030182 neuron differentiation
GO:0032011 ARF protein signal transduction
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:1918215
InterPro IPR000904 Sec7 domain
IPR001849 Pleckstrin homology domain
PFAM PF01369
PF00169
PRINTS
PIRSF
SMART SM00222
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2PFD7
PhosphoSite PhosphoSite-Q2PFD7
TrEMBL
UniProt Splice Variant
Entrez Gene 234353
UniGene Mm.413659
RefSeq NP_808366
MGI ID
MGI Symbol Psd3
OMIM
CCDS
HPRD
IMGT
EMBL AB220685 AK028684 AK122405 AK161498 BC042208
GenPept AAH42208 BAC26065 BAC65687 BAE36424 BAE73186

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca