InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Herc4

Summary

InnateDB Protein

IDBP-159159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Herc4

Protein Name

hect domain and RLD 4

Synonyms

1700056O17Rik; 4921531D01Rik; 9530080M15Rik; mKIAA1593;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020258

InnateDB Gene

IDBG-159157 (Herc4)

Protein Structure

UniProt Annotation

Function

Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. {ECO:0000269PubMed:17967448}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, highest expression is found in testis during spermiogenesis. It is specifically found in spermatogonia, spermatocytes, and spermatids with little or no expression detectable in the spermatozoa, or interstitial cells. {ECO:0000269PubMed:17967448}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0016874	ligase activity

Biological Process

GO:0007283	spermatogenesis
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1914595

InterPro

IPR000408 Regulator of chromosome condensation, RCC1
IPR000569 HECT
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

PFAM

PF00415
PF00632

PRINTS

PR00633

PIRSF

SMART

SM00119

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt