Version 5.4
| Mus musculus Protein: Tmprss6 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-159252.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tmprss6 | ||||||||
| Protein Name | transmembrane serine protease 6 | ||||||||
| Synonyms | 1300008A22Rik; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000017086 | ||||||||
| InnateDB Gene | IDBG-159250 (Tmprss6) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency (By similarity). May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter. {ECO:0000250, ECO:0000269PubMed:18451267}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:12744720}; Single-pass type II membrane protein {ECO:0000269PubMed:12744720}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed at highest levels in adult mice liver, kidney and uterus. Also strongly expressed within the nasal cavity by olfactory epithelial cells. A weak, but detectable, signal in adult mice tissues analyzed including brain, lung, heart, kidney, spleen, muscle, intestine, thymus and pancreas. No signal in residual embryonic yolk sac, developing kidney tubules or in embryonic tissues analyzed including lung, heart, gastrointestinal tract and epithelium of the oral cavity. {ECO:0000269PubMed:12744720}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1919003 | ||||||||
| InterPro |
IPR000082
SEA domain IPR000859 CUB domain IPR001254 Peptidase S1 IPR001314 Peptidase S1A, chymotrypsin-type IPR002172 Low-density lipoprotein (LDL) receptor class A repeat IPR009003 Trypsin-like cysteine/serine peptidase domain IPR015420 Peptidase S1A, nudel IPR017118 Peptidase S1A, matriptase-2 |
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| PFAM |
PF01390
PF00431 PF00089 PF00057 PF09342 |
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| PRINTS |
PR00722
PR00261 |
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| PIRSF |
PIRSF037135
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| SMART |
SM00200
SM00042 SM00020 SM00192 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9DBI0 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 71753 | ||||||||
| UniGene | Mm.34056 | ||||||||
| RefSeq | NP_082178 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Tmprss6 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS37133 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK004939 AL590144 AY240929 BC029645 BC057674 BK000520 EU190436 EU190437 | ||||||||
| GenPept | AAH29645 AAH57674 AAP69827 ABW38782 ABW38783 BAB23684 DAA00246 | ||||||||