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InnateDB Protein
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IDBP-159267.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sh2d4a
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Protein Name
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SH2 domain containing 4A
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Synonyms
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2210402M20Rik; SH2A;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000070825
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InnateDB Gene
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IDBG-159265 (Sh2d4a)
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Protein Structure
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| Function |
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation (By similarity). May play a role in T-cell development and function. {ECO:0000250, ECO:0000269PubMed:18641339}.
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| Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:17251388}. Note=Located at podocyte foot processes.
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| Disease Associations |
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| Tissue Specificity |
In the kidney, expressed only in the glomerulus. Expressed in T-cells, B-cells, macrophages and dendritic cells (at protein level). In adult, highest levels are found in muscle and lung with lower levels in kidney. {ECO:0000269PubMed:17251388, ECO:0000269PubMed:18641339}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
8 [view]
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Molecular Function |
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| Biological Process |
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GO:0010923
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negative regulation of phosphatase activity
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| Cellular Component |
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| PDB ID |
MGI:1919531
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| InterPro |
IPR000980
SH2 domain
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| PFAM |
PF00017
PF14633
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| PRINTS |
PR00401
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| PIRSF |
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| SMART |
SM00252
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q9D7V1
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| PhosphoSite |
PhosphoSite-Q9D7V1
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
72281
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| UniGene |
Mm.40974
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| RefSeq |
NP_082458
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| MGI ID |
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| MGI Symbol |
Sh2d4a
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| OMIM |
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| CCDS |
CCDS52564
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| HPRD |
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| IMGT |
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| EMBL |
AK008803
BC116682
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| GenPept |
AAI16683
BAB25905
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Version 5.4