InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcan

Summary

InnateDB Protein

IDBP-159273.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcan

Protein Name

brevican

Synonyms

Cspg7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088491

InnateDB Gene

IDBG-159271 (Bcan)

Protein Structure

UniProt Annotation

Function

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0030246	carbohydrate binding

Biological Process

GO:0007155	cell adhesion
GO:0021766	hippocampus development

Cellular Component

GO:0005578

proteinaceous extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1096385

InterPro

IPR000436 Sushi/SCR/CCP
IPR000538 Link
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR001881 EGF-like calcium-binding domain
IPR002353 Type-2 ice-structuring protein
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016187 C-type lectin fold

PFAM

PF00084
PF00193
PF00008
PF00059
PF07645
PF07686

PRINTS

PR01265
PR00356

PIRSF

SMART