InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mpdz

Summary

InnateDB Protein

IDBP-159282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mpdz

Protein Name

multiple PDZ domain protein

Synonyms

AI225843; B930003D11Rik; MUPP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099894

InnateDB Gene

IDBG-159280 (Mpdz)

Protein Structure

UniProt Annotation

Function

Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

In the brain, it is strongly expressed in the choroid plexus. Within the hippocampal formation, strongest expression was seen in the soma of CA1-4 pyramidal cells. Expressed in most neocortical regions with the strongest expression in piriform cortex and amygdaloid nuclei but also detected in the subiculum and olfactory bulb. In the cerebellum, the highest level of expression was found in Purkinje cells. Moderately expressed in the granular layer and molecular layer. Expressed in the pontine nuclei, parts of spinal trigeminal nuclei, and the principal sensory trigeminal nuclei of the metencephalon. Expressed in all thalamic and hypothalamic nuclei, and the substantia nigra (at protein level). Ubiquitously expressed. {ECO:0000269PubMed:11018522, ECO:0000269PubMed:12706259}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0007155	cell adhesion
GO:0042552	myelination

Cellular Component

GO:0005737	cytoplasm
GO:0005923	tight junction
GO:0014069	postsynaptic density
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0043220	Schmidt-Lanterman incisure
GO:0045211	postsynaptic membrane