InnateDB Protein
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IDBP-159332.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Csgalnact1
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Protein Name
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chondroitin sulfate N-acetylgalactosaminyltransferase 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000077459
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InnateDB Gene
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IDBG-159330 (Csgalnact1)
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Protein Structure
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Function |
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage. {ECO:0000269PubMed:17145758}.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0008376
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acetylgalactosaminyltransferase activity
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GO:0008955
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peptidoglycan glycosyltransferase activity
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GO:0015020
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glucuronosyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0046872
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metal ion binding
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GO:0047237
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glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
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GO:0047238
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glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
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Biological Process |
GO:0001958
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endochondral ossification
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GO:0019276
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UDP-N-acetylgalactosamine metabolic process
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GO:0030198
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extracellular matrix organization
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GO:0030204
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chondroitin sulfate metabolic process
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GO:0030206
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chondroitin sulfate biosynthetic process
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GO:0046398
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UDP-glucuronate metabolic process
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GO:0050653
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chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
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GO:0051216
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cartilage development
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Cellular Component |
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PDB ID |
MGI:2442354
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InterPro |
IPR008428
Chondroitin N-acetylgalactosaminyltransferase
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF05679
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BJQ9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
234356
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UniGene |
Mm.489712
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RefSeq |
NP_766341
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MGI ID |
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MGI Symbol |
Csgalnact1
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OMIM |
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CCDS |
CCDS22341
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HPRD |
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IMGT |
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EMBL |
AK028688
AK033522
AK049770
AK080687
AK133567
AK144089
BC026599
BC089162
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GenPept |
AAH26599
AAH89162
BAC26066
BAC28340
BAC33912
BAC37982
BAE21729
BAE25692
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