InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vash1

Summary

InnateDB Protein

IDBP-159338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vash1

Protein Name

vasohibin 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021681

InnateDB Gene

IDBG-159336 (Vash1)

Protein Structure

UniProt Annotation

Function

Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0001525	angiogenesis
GO:0001937	negative regulation of endothelial cell proliferation
GO:0007050	cell cycle arrest
GO:0009611	response to wounding
GO:0010596	negative regulation of endothelial cell migration
GO:0010628	positive regulation of gene expression
GO:0016525	negative regulation of angiogenesis
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:1901491	negative regulation of lymphangiogenesis
GO:2000772	regulation of cellular senescence