InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hapln2

Summary

InnateDB Protein

IDBP-159392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hapln2

Protein Name

hyaluronan and proteoglycan link protein 2

Synonyms

4930401E20Rik; Bral1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005014

InnateDB Gene

IDBG-159388 (Hapln2)

Protein Structure

UniProt Annotation

Function

Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Brain. Predominantly expressed by neurons. Colocalizes with versican V2 in developing and adult cerebellar white matter and at the nodes of Ranvier. {ECO:0000269PubMed:11027579}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding

Biological Process

GO:0007155	cell adhesion
GO:0008065	establishment of blood-nerve barrier
GO:0085029	extracellular matrix assembly

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:2137300

InterPro

IPR000538 Link
IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR016187 C-type lectin fold

PFAM

PF00193
PF07686
PF00047

PRINTS

PR01265

PIRSF

SMART

SM00445
SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt