InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Katnal2

Summary

InnateDB Protein

IDBP-159440.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Katnal2

Protein Name

katanin p60 subunit A-like 2

Synonyms

3110023G01Rik; 4933439B08Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026486

InnateDB Gene

IDBG-159438 (Katnal2)

Protein Structure

UniProt Annotation

Function

Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. {ECO:0000255HAMAP-Rule:MF_03025}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000255HAMAP- Rule:MF_03025}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008568	microtubule-severing ATPase activity
GO:0009378	four-way junction helicase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0008150	biological_process
GO:0051013	microtubule severing

Cellular Component

GO:0005575	cellular_component
GO:0005737	cytoplasm
GO:0005874	microtubule

Protein Structure and Domains

PDB ID

MGI:1924234

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR006594 LisH dimerisation motif
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR013720 LisH dimerisation motif, subgroup
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496
PF08513

PRINTS

PIRSF

SMART

SM00382
SM00667

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D3R6