InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msx1

Summary

InnateDB Protein

IDBP-159454.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msx1

Protein Name

homeobox, msh-like 1

Synonyms

AA675338; AI324650; Hox-7; Hox7; Hox7.1; msh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058354

InnateDB Gene

IDBG-159452 (Msx1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. {ECO:0000269PubMed:1677742, ECO:0000269PubMed:7823952}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	20 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0001837	epithelial to mesenchymal transition
GO:0003007	heart morphogenesis
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0007517	muscle organ development
GO:0008285	negative regulation of cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0010463	mesenchymal cell proliferation
GO:0021983	pituitary gland development
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030262	apoptotic nuclear changes
GO:0030308	negative regulation of cell growth
GO:0030326	embryonic limb morphogenesis
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0034504	protein localization to nucleus
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0035880	embryonic nail plate morphogenesis
GO:0042474	middle ear morphogenesis
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042476	odontogenesis
GO:0042481	regulation of odontogenesis
GO:0042733	embryonic digit morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048863	stem cell differentiation
GO:0050821	protein stabilization
GO:0051154	negative regulation of striated muscle cell differentiation
GO:0051216	cartilage development
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0060349	bone morphogenesis
GO:0060536	cartilage morphogenesis
GO:0061180	mammary gland epithelium development
GO:0061312	BMP signaling pathway involved in heart development
GO:0071316	cellular response to nicotine
GO:0090427	activation of meiosis
GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2001055	positive regulation of mesenchymal cell apoptotic process