Version 5.4
Mus musculus Protein: Ctnna3
Summary
InnateDB Protein IDBP-159582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctnna3
Protein Name catenin (cadherin associated protein), alpha 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000074606
InnateDB Gene IDBG-159580 (Ctnna3)
Protein Structure
UniProt Annotation
Function May be involved in formation of stretch-resistant cell- cell adhesion complexes. {ECO:0000250UniProtKB:Q9UI47}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0045296 cadherin binding
Biological Process
GO:0007155 cell adhesion
GO:0016337 single organismal cell-cell adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0005916 fascia adherens
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID MGI:2661445
InterPro IPR001033 Alpha-catenin
IPR006077 Vinculin/alpha-catenin
PFAM PF01044
PRINTS PR00805
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q65CL1
PhosphoSite PhosphoSite-Q65CL1
TrEMBL
UniProt Splice Variant
Entrez Gene 216033
UniGene Mm.483238
RefSeq XP_006513540
MGI ID
MGI Symbol Ctnna3
OMIM
CCDS CCDS23901
HPRD
IMGT
EMBL AF344871 AK030166 AK142745
GenPept AAQ14965 BAC26817 BAE25182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca