Version 5.4
Mus musculus Protein: St8sia5
Summary
InnateDB Protein IDBP-159599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol St8sia5
Protein Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000074764
InnateDB Gene IDBG-159595 (St8sia5)
Protein Structure
UniProt Annotation
Function May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in brain. Expressed at low levels in other tissues, including liver, testis, lung, placenta and spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0097503 sialylation
Cellular Component
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID MGI:109243
InterPro IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
PFAM PF00777
PRINTS
PIRSF PIRSF005557
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70126
PhosphoSite PhosphoSite-P70126
TrEMBL
UniProt Splice Variant
Entrez Gene 225742
UniGene Mm.365178
RefSeq NP_038694
MGI ID
MGI Symbol St8sia5
OMIM
CCDS CCDS50325
HPRD
IMGT
EMBL AC157991 X98014
GenPept CAA66642 CAA66643 CAA66644

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca