InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd28

Summary

InnateDB Protein

IDBP-159610.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd28

Protein Name

CD28 antigen

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027165

InnateDB Gene

IDBG-159608 (Cd28)

Protein Structure

UniProt Annotation

Function

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0002863	positive regulation of inflammatory response to antigenic stimulus
GO:0006955	immune response
GO:0009967	positive regulation of signal transduction
GO:0031295	T cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0045060	negative thymic T cell selection
GO:0045066	regulatory T cell differentiation
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050852	T cell receptor signaling pathway
GO:0097190	apoptotic signaling pathway