Version 5.4
Mus musculus Protein: Aup1
Summary
InnateDB Protein IDBP-159651.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aup1
Protein Name ancient ubiquitous protein 1
Synonyms AA589454;
Species Mus musculus
Ensembl Protein ENSMUSP00000090281
InnateDB Gene IDBG-159649 (Aup1)
Protein Structure
UniProt Annotation
Function May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:107789
InterPro IPR003892 Ubiquitin system component Cue
PFAM PF02845
PRINTS
PIRSF
SMART SM00546
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70295
PhosphoSite PhosphoSite-P70295
TrEMBL Q3U3K9
UniProt Splice Variant
Entrez Gene 11993
UniGene
RefSeq NP_031543
MGI ID
MGI Symbol Aup1
OMIM
CCDS CCDS39526
HPRD
IMGT
EMBL AC104324 AK154707 AK158035 AK171011 BC012699 BC016485 CH466523 U41736
GenPept AAC52839 AAH12699 AAH16485 BAE32776 BAE34327 BAE42182 EDK99051

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca