InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rhbdf1

Summary

InnateDB Protein

IDBP-159658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rhbdf1

Protein Name

rhomboid family 1 (Drosophila)

Synonyms

C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020524

InnateDB Gene

IDBG-159654 (Rhbdf1)

Protein Structure

UniProt Annotation

Function

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized in the endoplasmic reticulum membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the duodenum, as well as in fetal liver and head. {ECO:0000269PubMed:8318735}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0008283	cell proliferation
GO:0016477	cell migration
GO:0042058	regulation of epidermal growth factor receptor signaling pathway
GO:0050708	regulation of protein secretion
GO:0050709	negative regulation of protein secretion
GO:0061136	regulation of proteasomal protein catabolic process