Version 5.4
Mus musculus Protein: Loxhd1
Summary
InnateDB Protein IDBP-159729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Loxhd1
Protein Name lipoxygenase homology domains 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000094294
InnateDB Gene IDBG-159725 (Loxhd1)
Protein Structure
UniProt Annotation
Function Required for normal function of hair cells in the inner ear. {ECO:0000269PubMed:19732867}.
Subcellular Localization Cell projection, stereocilium {ECO:0000269PubMed:19732867}.
Disease Associations
Tissue Specificity Expressed in the inner ear, specifically in hair cells. Higher expression is detected in the cochlea. {ECO:0000269PubMed:19732867}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0007605 sensory perception of sound
GO:0050982 detection of mechanical stimulus
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0032420 stereocilium
Protein Structure and Domains
PDB ID MGI:1914609
InterPro IPR001024 PLAT/LH2 domain
IPR008976 Lipase/lipooxygenase, PLAT/LH2
PFAM PF01477
PRINTS
PIRSF
SMART SM00308
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt C8YR32
PhosphoSite PhosphoSite-C8YR32
TrEMBL F6QGA9
UniProt Splice Variant
Entrez Gene 240411
UniGene Mm.380247
RefSeq NP_766422
MGI ID
MGI Symbol Loxhd1
OMIM
CCDS CCDS50326
HPRD
IMGT
EMBL AC102124 AC102135 AK007091 FJ750876
GenPept ACV52550 BAC25164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca