InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nprl3

Summary

InnateDB Protein

IDBP-159763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nprl3

Protein Name

nitrogen permease regulator-like 3 (S. cerevisiae)

Synonyms

Aag; CGTHBA; HS-26; HS-40; m(alpha)RE; Mare; Phg; Prox1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020530

InnateDB Gene

IDBG-159761 (Nprl3)

Protein Structure

UniProt Annotation

Function

As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC- containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005096	GTPase activator activity

Biological Process

GO:0003281	ventricular septum development
GO:0035909	aorta morphogenesis
GO:0043547	positive regulation of GTPase activity
GO:0048738	cardiac muscle tissue development
GO:0060021	palate development