InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pank1

Summary

InnateDB Protein

IDBP-159903.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pank1

Protein Name

pantothenate kinase 1

Synonyms

Pank; Pank1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043562

InnateDB Gene

IDBG-159901 (Pank1)

Protein Structure

UniProt Annotation

Function

Plays a role in the physiological regulation of the intracellular CoA concentration.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in liver and kidney. Isoform 1 is highly expressed in heart and skeletal muscle, whereas isoform 2 is expressed exclusively in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004594	pantothenate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0015937	coenzyme A biosynthetic process
GO:0016310	phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0030118	clathrin coat
GO:0055037	recycling endosome
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:1922985

InterPro

IPR004567 Type II pantothenate kinase

PFAM

PF03630

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K4K6

PhosphoSite

PhosphoSite-Q8K4K6

TrEMBL

UniProt Splice Variant

Entrez Gene

75735

UniGene

Mm.24742

RefSeq

NP_001107811

MGI ID

MGI Symbol

Pank1

OMIM

CCDS

CCDS50424

HPRD

IMGT

EMBL

AF200357 AF347700 AK017345 BC023496

GenPept

AAF23952 AAH23496 AAM77216 BAB30700