InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptges2

Summary

InnateDB Protein

IDBP-160126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptges2

Protein Name

prostaglandin E synthase 2

Synonyms

0610038H10Rik; C79137; Gbf1; Mpges2; Pges2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028162

InnateDB Gene

IDBG-160124 (Ptges2)

Protein Structure

UniProt Annotation

Function

Dual function enzyme which exhibits both isomerase and lyase activities. Its catalytic activity is altered by the presence or absence of the cofactors glutathione (GSH) and heme. The GSH-heme complex-bound enzyme (mPGES-2h) acts as a lyase and catalyzes the degradation of prostaglandin E2 H2 (PGH2) to 12(S)- hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) while the GSH-heme complex-free enzyme (mPGES-2) acts as an isomerase and catalyzes the isomerization of PGH2 into the more stable prostaglandin E2 (PGE2) form (By similarity). May also have transactivation activity toward IFN- gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane; Single-pass membrane protein. Nucleus. Note=According to PubMed:12050152, some fraction may be nuclear.Prostaglandin E synthase 2 truncated form: Cytoplasm. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in brain, heart, liver, colon and lung. {ECO:0000269PubMed:12050152, ECO:0000269PubMed:12835322}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0016829	lyase activity
GO:0020037	heme binding
GO:0043295	glutathione binding
GO:0050220	prostaglandin-E synthase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045454	cell redox homeostasis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046903	secretion
GO:0055114	oxidation-reduction process