Version 5.4
Homo sapiens Protein: RBP5
Summary
InnateDB Protein IDBP-16016.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBP5
Protein Name retinol binding protein 5, cellular
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000266560
InnateDB Gene IDBG-16014 (RBP5)
Protein Structure
UniProt Annotation
Function Intracellular transport of retinol. {ECO:0000269PubMed:11274389}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Higher expression in adult kidney and liver and to a lesser extent in adult and fetal spleen, adult lymph nodes and appendix, and fetal liver and kidney. Strongly decreased in hepatocellular carcinoma tissues (at protein level). {ECO:0000269PubMed:11274389, ECO:0000269PubMed:17497168}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005501 retinoid binding
GO:0016918 retinal binding
GO:0019841 retinol binding
Biological Process
GO:0006810 transport
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR011038 Calycin-like
PFAM PF00061
PF08212
PRINTS PR00178
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P82980
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 83758
UniGene
RefSeq NP_113679
HUGO HGNC:15847
OMIM 611866
CCDS CCDS8574
HPRD 17961
IMGT
EMBL AF212239 AK223378 AK311977 AY007436 BC029355
GenPept AAG09617 AAH29355 AAK14925 BAD97098 BAG34916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca