InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPEF2

Summary

InnateDB Protein

IDBP-16019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPEF2

Protein Name

sperm flagellar 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000348314

InnateDB Gene

IDBG-16017 (SPEF2)

Protein Structure

UniProt Annotation

Function

Required for correct axoneme development. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0002520	immune system development
GO:0007283	spermatogenesis
GO:0009566	fertilization
GO:0010259	multicellular organismal aging
GO:0035082	axoneme assembly
GO:0048702	embryonic neurocranium morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0048854	brain morphogenesis
GO:0060271	cilium morphogenesis
GO:0060541	respiratory system development

Cellular Component

GO:0002177	manchette
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0097225	sperm midpiece

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR008906 HAT dimerisation domain, C-terminal
IPR010441 Protein of unknown function DUF1042
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00307
PF05699
PF06294

PRINTS

PIRSF

SMART

SM00033

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9C093