Version 5.4
Mus musculus Protein: Cts7
Summary
InnateDB Protein IDBP-160199.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cts7
Protein Name cathepsin 7
Synonyms AA408230; AA408952; CTS1; Epcs24; Epcs71;
Species Mus musculus
Ensembl Protein ENSMUSP00000021892
InnateDB Gene IDBG-160197 (Cts7)
Protein Structure
UniProt Annotation
Function Involved in trophoblast cell proliferation and differentiation probably by affecting mitotic cell cycle progression. Proteolytic activity and nuclear localization are essential for its role in cell cycle progression. {ECO:0000269PubMed:18776147}.
Subcellular Localization Endosome {ECO:0000269PubMed:18776147, ECO:0000305}. Lysosome {ECO:0000269PubMed:18776147, ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269PubMed:18776147}. Golgi apparatus {ECO:0000269PubMed:18776147, ECO:0000305}. Nucleus {ECO:0000269PubMed:18776147}. Secreted, extracellular space {ECO:0000269PubMed:18776147}.
Disease Associations
Tissue Specificity Expressed in placenta. Expressed in parietal and spiral artery-associated trophoblast giant cells, most abundantly during the phase of trophoblast invasion. From E14.5 onwards, expressed at lower levels in labyrinth trophoblast cells. Expressed in trophoblast stem cells. Expressed in heart, liver and testis. {ECO:0000269PubMed:10885754, ECO:0000269PubMed:11829493, ECO:0000269PubMed:18776147}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007067 mitotic nuclear division
GO:0045930 negative regulation of mitotic cell cycle
GO:0060707 trophoblast giant cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1860262
InterPro IPR000668 Peptidase C1A, papain C-terminal
IPR013201 Proteinase inhibitor I29, cathepsin propeptide
PFAM PF00112
PF08246
PRINTS PR00705
PIRSF
SMART SM00645
SM00848
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91ZF2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56092
UniGene
RefSeq NP_062412
MGI ID
MGI Symbol Cts7
OMIM
CCDS CCDS26588
HPRD
IMGT
EMBL AF250837 AY014779 BC064740 CH466546 CT030645
GenPept AAF81274 AAH64740 AAK00508 EDL41318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca