Version 5.4
Mus musculus Protein: Pla1a
Summary
InnateDB Protein IDBP-160202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla1a
Protein Name phospholipase A1 member A
Synonyms AA986889; Ps-pla1; Pspla1;
Species Mus musculus
Ensembl Protein ENSMUSP00000002926
InnateDB Gene IDBG-160200 (Pla1a)
Protein Structure
UniProt Annotation
Function Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016787 hydrolase activity
Biological Process
GO:0008150 biological_process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1934677
InterPro IPR000734 Lipase
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00151
PRINTS PR00821
PIRSF PIRSF000865
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VI78
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 85031
UniGene Mm.413788
RefSeq NP_598863
MGI ID
MGI Symbol Pla1a
OMIM
CCDS CCDS28166
HPRD
IMGT
EMBL AC154809 AF063498 BC003470 BC030670 CAAA01219438 CT571259
GenPept AAH03470 AAH30670 AAL55475

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca