InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sh3pxd2b

Summary

InnateDB Protein

IDBP-160215.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sh3pxd2b

Protein Name

SH3 and PX domains 2B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044276

InnateDB Gene

IDBG-160213 (Sh3pxd2b)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation. {ECO:0000269PubMed:18959745, ECO:0000269PubMed:19144821, ECO:0000269PubMed:19755710}.

Subcellular Localization

Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.

Disease Associations

Tissue Specificity

Highly expressed in the stromal-vascular fraction of white adipose tissue with moderate expression in heart, skeletal muscle and the mature adipocyte fraction of white adipose tissue. Also expressed in brain, spleen, kidney and liver. Expressed in white and brown adipose tissues, eye, lung, heart, brain, spleen, stomach, liver and skeletal muscle (at protein level). Not expressed in kidney or bone marrow. {ECO:0000269PubMed:18959745, ECO:0000269PubMed:19144821, ECO:0000269PubMed:19669234}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0010314	phosphatidylinositol-5-phosphate binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0035091	phosphatidylinositol binding
GO:0042169	SH2 domain binding
GO:0070273	phosphatidylinositol-4-phosphate binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0001501	skeletal system development
GO:0001654	eye development
GO:0006801	superoxide metabolic process
GO:0007507	heart development
GO:0022617	extracellular matrix disassembly
GO:0030154	cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0060348	bone development
GO:0060612	adipose tissue development
GO:0071800	podosome assembly
GO:0072657	protein localization to membrane

Cellular Component

GO:0002102	podosome
GO:0005737	cytoplasm
GO:0030054	cell junction
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

MGI:2442062

InterPro

IPR001452 SH3 domain
IPR001683 Phox homologous domain
IPR003646 SH3-like domain, bacterial-type
IPR010466 Protein of unknown function DUF1058
IPR011511 Variant SH3 domain

PFAM