InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp13a1

Summary

InnateDB Protein

IDBP-160242.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp13a1

Protein Name

ATPase type 13A1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034326

InnateDB Gene

IDBG-160240 (Atp13a1)

Protein Structure

UniProt Annotation

Function

Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006812	cation transport

Cellular Component

GO:0005575	cellular_component
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2180801

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR006544 Cation-transporting P-type ATPase, subfamily V
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF12409
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EPE9