InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMPRSS9

Summary

InnateDB Protein

IDBP-16028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMPRSS9

Protein Name

transmembrane protease, serine 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000330264

InnateDB Gene

IDBG-16026 (TMPRSS9)

Protein Structure

UniProt Annotation

Function

Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln- Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala- Pro-Ala-AMC are not significantly hydrolyzed.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12886014}; Single-pass type II membrane protein {ECO:0000269PubMed:12886014}.

Disease Associations

Tissue Specificity

Expressed in fetal human tissues, such as kidney, liver, lung and brain, and in a variety of tumor cell lines. Weakly expressed in adult tissues including skeletal muscle, liver, placenta and heart. {ECO:0000269PubMed:12886014}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0031639	plasminogen activation

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017324 Peptidase S1A, polyserase-1

PFAM

PF00089
PF00057
PF09342

PRINTS

PR00722
PR00261

PIRSF

PIRSF037931

SMART

SM00020
SM00192

TIGRFAMs

Post-translational Modifications

Modification

Cross-References