InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stk10

Summary

InnateDB Protein

IDBP-160372.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stk10

Protein Name

serine/threonine kinase 10

Synonyms

Gek1; Lok; mKIAA4026;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099885

InnateDB Gene

IDBG-160368 (Stk10)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269PubMed:19255442}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in lymphoid organs such as spleen, thymus, and bone marrow.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation
GO:0071593	lymphocyte aggregation
GO:2000401	regulation of lymphocyte migration

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1099439

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022165 Polo kinase kinase

PFAM

PF00069
PF07714
PF12474

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt