InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dpm2

Summary

InnateDB Protein

IDBP-160389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpm2

Protein Name

dolichol-phosphate (beta-D) mannosyltransferase 2

Synonyms

AW557993; R75484;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028151

InnateDB Gene

IDBG-160387 (Dpm2)

Protein Structure

UniProt Annotation

Function

Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0005515	protein binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0006486	protein glycosylation
GO:0006506	GPI anchor biosynthetic process
GO:0009059	macromolecule biosynthetic process
GO:0019348	dolichol metabolic process
GO:0031647	regulation of protein stability
GO:0050790	regulation of catalytic activity
GO:0097502	mannosylation

Cellular Component

GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0033185	dolichol-phosphate-mannose synthase complex
GO:0048471	perinuclear region of cytoplasm