Version 5.4
Mus musculus Protein: Poglut1
Summary
InnateDB Protein IDBP-160417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Poglut1
Protein Name protein O-glucosyltransferase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000038166
InnateDB Gene IDBG-160415 (Poglut1)
Protein Structure
UniProt Annotation
Function Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding. {ECO:0000269PubMed:21949356}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed in newborn and adult tissues (at protein level). {ECO:0000269PubMed:21490058}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030158 protein xylosyltransferase activity
GO:0035251 UDP-glucosyltransferase activity
GO:0035252 UDP-xylosyltransferase activity
GO:0046527 glucosyltransferase activity
Biological Process
GO:0006493 protein O-linked glycosylation
GO:0008593 regulation of Notch signaling pathway
GO:0072358 cardiovascular system development
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2444232
InterPro IPR006598 Lipopolysaccharide-modifying protein
PFAM PF05686
PRINTS
PIRSF
SMART SM00672
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BYB9
PhosphoSite PhosphoSite-Q8BYB9
TrEMBL Q8BLG5
UniProt Splice Variant
Entrez Gene 224143
UniGene Mm.284366
RefSeq NP_759012
MGI ID
MGI Symbol Poglut1
OMIM
CCDS CCDS28170
HPRD
IMGT
EMBL AK031608 AK035948 AK036224 AK041321 AK045278 AK167641 BC026809
GenPept AAH26809 BAC27475 BAC29255 BAC29351 BAC30905 BAC32292 BAE39692

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca