Version 5.4
Mus musculus Protein: Hs3st1
Summary
InnateDB Protein IDBP-160453.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hs3st1
Protein Name heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Synonyms 3-Ost; D5Wsu110e; Hsg3ost;
Species Mus musculus
Ensembl Protein ENSMUSP00000051055
InnateDB Gene IDBG-160451 (Hs3st1)
Protein Structure
UniProt Annotation
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. {ECO:0000269PubMed:9346953}.
Subcellular Localization Golgi apparatus lumen {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
Protein Structure and Domains
PDB ID MGI:1201606
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35310
PhosphoSite PhosphoSite-
TrEMBL D3YZM3
UniProt Splice Variant
Entrez Gene 15476
UniGene Mm.427791
RefSeq NP_034604
MGI ID 3UAN
MGI Symbol Hs3st1
OMIM
CCDS CCDS19257
HPRD
IMGT
EMBL AC098713 AC144779 AF019385 AK087753 BC009133
GenPept AAB84387 AAH09133 BAC39991

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca