Version 5.4
Mus musculus Protein: Pip5kl1
Summary
InnateDB Protein IDBP-160469.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pip5kl1
Protein Name phosphatidylinositol-4-phosphate 5-kinase-like 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051282
InnateDB Gene IDBG-160465 (Pip5kl1)
Protein Structure
UniProt Annotation
Function May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. {ECO:0000269PubMed:14701839}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14701839}. Membrane {ECO:0000269PubMed:14701839}. Note=Localized to large cytoplasmic vesicular structures.
Disease Associations
Tissue Specificity Highly expressed in brain and testis, relatively to heart, spleen, lung, liver, skeletal muscle and kidney. {ECO:0000269PubMed:14701839}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
Biological Process
GO:0046488 phosphatidylinositol metabolic process
GO:0046854 phosphatidylinositol phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042995 cell projection
Protein Structure and Domains
PDB ID MGI:2448520
InterPro IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
PFAM PF01504
PRINTS
PIRSF
SMART SM00330
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6U7H8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 227733
UniGene
RefSeq NP_937834
MGI ID
MGI Symbol Pip5kl1
OMIM
CCDS CCDS15920
HPRD
IMGT
EMBL AK133244 AK164998 AL928710 AY376879 BC028795 BC094346 BC117018 BC119037
GenPept AAH28795 AAH94346 AAI17019 AAI19038 AAQ92365 BAE21576 BAE37997 CAM18808

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca